Clathrin associated adaptor protein ap complexes are main clathrin adaptors contributing to the formation of ccvs kirchhausen 2000. 2014 determined a structure of ap2 that includes the clathrin binding beta 2 hinge and developed an ap2 dependent budding assay. It is presumed that endocytosis begins with the formation of pits on the inner surface of the cytoplasmic membrane containing clathrin the ap 2 adaptor protein complex and accessory proteins.
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