Adaptor Protein Binding Domain

Ww domain binding protein 2 wbp2 as a binding partner of ww domain protein interacts with several ww domain containing proteins such as yes kinase associated protein yap paired box gene 8 pax8 ww domain containing transcription regulator protein 1 taz and.

Adaptor protein binding domain. Biochemical biophysical and cellular experiments now show that the mint1 phosphotyrosine binding ptb domain that binds to app is intramolecularly. 1998 reported that when doc2 was transfected into an ovarian carcinoma cell line the stable transfectants showed significantly reduced growth rate and ability to form tumors in nude mice. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. The protein encoded by this gene is a tir adaptor protein involved.

Different tlrs recognize different pathogen associated molecular patterns and all tlrs have a toll interleukin 1 receptor tir domain which is responsible for signal transduction. The innate immune system recognizes microbial pathogens through toll like receptors tlrs which identify pathogen associated molecular patterns. It possesses an n terminal pb1 phox and bem1p domain that interacts with a number of signaling molecules such as atypical protein kinase c apkc and mek5 but also mediates p62 self. Growth factor receptors with intrinsic kinase activity and those that signal through g proteins can promote tyrosine phosphorylation of the adaptor protein shc which link activated growth factor receptors to the ras signaling pathway and its subsequent association with the grb2 sos growth factor receptor binding protein 2 son of sevenless.

The protein encoded by this gene has been identified as a brain specific angiogenesis inhibitor bai1 binding protein. Fas associated protein with death domain fadd also called mort1 is encoded by the fadd gene on the 11q13 3 region of chromosome 11 in humans. Fadd is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily such as the fas receptor to procaspases 8 and 10 to form the death inducing signaling complex disc during apoptosis. 1998 found evidence that dab2 interacts with grb2 an adaptor protein that couples tyrosine kinase receptors to sos by coimmunoprecipitation of a mouse macrophage like cell.

The ww domain is composed of 38 to 40 semi conserved amino acids shared with structural regulatory and signaling proteins. Adaptor proteins contain a variety of protein binding modules that link protein binding partners together and facilitate the creation of larger signaling complexes. Adaptor proteins contain a variety of protein binding modules that link protein binding partners together and facilitate the creation of larger signaling complexes. Mint adaptor proteins bind to the amyloid precursor protein app and regulate app processing associated with alzheimer s disease.

The adaptor protein p62 sqstm1 or simply p62 figure 4 3a was the first selective autophagy receptor described in mammalian cells pankiv et al 2007. Signal transducing adaptor proteins staps are proteins that are accessory to main proteins in a signal transduction pathway.