Adaptor Protein Complex 2

The encoded protein may also play an important role in regulating the.

Adaptor protein complex 2. Here we present evidence that endocytosis involving heterotetrameric adaptor protein complex 2 ap 2. The ap2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin mediated endocytosis. The encoded protein is required for the activity of a vacuolar atpase which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The complex consists of 2 large 100 kd components which are called the alpha and beta subunits a 50 kd component ap50 and a small 17 kd protein summary by thurieau et al 1988.

The ap adaptor protein complexes are heterotetrameric protein complexes that mediate intracellular membrane trafficking along endocytic and secretory transport pathways. This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 ap2 which belongs to the adaptor complexes medium subunits family. Ap 1 ap 2 and ap 3 are clathrin associated complexes. Whereas ap 4 and ap 5 are not.

However it remains elusive as to how this coordination occurs during reproduction. Ap 2 is involved in clathrin dependent endocytosis in which cargo proteins are incorporated into. These appendage domains are sometimes called ears. There are five different ap complexes.

Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. Component of the adaptor protein complex 2 ap 2. Simpson et al 1996 by use of the yeast 2 hybrid system lim et al. The beta subunit of neuronal adaptin like protein beta nap is the target antigen in human paraneoplastic neurologic disorders newman et al 1995.

1998 demonstrated that atm protein which is mutated in ataxia telangiectasia binds to beta adaptin one of the components of the complex that is involved in clathrin. Ap50 is a 50 kd component of the ap2 coat assembly protein complex of clathrin coated vesicles. This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 ap2 adaptors complex found in clathrin coated vesicles the ap 2 complex is a heterotetramer consisting of two large adaptins alpha or beta a medium adaptin mu and a small adaptin sigma. Ap 2 complex subunit alpha 1 is a protein that in humans is encoded by the ap2a1 gene.

Fertilization in flowering plants requires the temporal and spatial coordination of many developmental processes including pollen production anther dehiscence ovule production and pollen tube elongation. Moreover aak1 is overexpressed specifically in dengue virus infected but not bystander cells.