Adaptor Protein Complex 3

Adaptor protein complex 3 is a descriptor in the national library of medicine s controlled vocabulary thesaurus mesh medical subject headings descriptors are arranged in a hierarchical structure which enables searching at various levels of specificity.

Adaptor protein complex 3. Ap 1 ap 2 and ap 3 are clathrin associated complexes. The ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Vangl2 interacts with adaptor protein 3 complex ap 3 we examined the association of vangl2 with a coat protein known to localize to endosomes for which a viable mouse null mutant exists. It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers.

The ap2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin mediated endocytosis. 42 immunologic studies. Clathrin adaptor proteins also known as adaptins are vesicular transport adaptor proteins associated with clathrin these proteins are synthesized in the ribosomes processed in the endoplasmic reticulum and transported from the golgi apparatus to the trans golgi network and from there via small carrier vesicles to their final destination compartment. Using a yeast 2 hybrid assay lefrancois et al.

These appendage domains are sometimes called ears. The ap adaptor protein complexes are heterotetrameric protein complexes that mediate intracellular membrane trafficking along endocytic and secretory transport pathways. 1997 found that claps3 which they designated sigma 3a is part of a large complex ap3 that appears to be a ubiquitously expressed adaptor like complex involved in protein sorting. Adaptor protein 3 complex deficient animal models have revealed some of the biochemical basis and intracellular mechanisms that mediate lysosomal sorting of a set of membrane proteins but the elucidation of a number of specific functions of ap 3 complex remained undefined until they were studied in patients with hps2.

The delta subunit of the coat protein complex adaptor protein 3 complex ap 3 is mutated in the mocha mouse ap3d1 mh mh kantheti et al 1998. Ap 3 is a heterotetrameric protein complex consisting of four subunits δ β µ and σ. There are five different ap complexes. 607246 interacts with both isoforms of the sigma 3 subunit sigma 3a.

Subunit of non clathrin and clathrin associated adaptor protein complex 3 ap 3 that plays a role in protein sorting in the late golgi trans golgi network tgn and or endosomes. Whereas ap 4 and ap 5 are not. Ap1s3 adaptor protein complex 1 sigma 1c subunit ap1s3.