Adaptor Protein Complexes And Disease At A Glance

Adaptor protein complex clathrin membrane traffic endocytosis golgi hereditary spastic paraplegia introduction. Furthermore patients with a range of disorders particularly involving the nervous system have now been identified with mutations in each of the ap complexes. 2 cambridge institute for medical research university of cambridge cambridge cb2 0xy uk msr12 cam ac uk.

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Five ap complexes ap 1 to ap 5 have been described each with a distinct localisation and function.

Adaptor protein complexes and disease at a glance. Ap 1 and ap 2 were first identified as assembly polypeptides 1 that could promote the assembly of clathrin in vitro. An inflammasome assembles in response to a diverse range of pathogen. Glance article and the accompanying poster we summarize what is known about the five ap complexes and discuss how this helps to explain the clinical features of the different genetic disorders. Inflammasomes are multimeric protein complexes that typically comprise a sensor an adaptor and the zymogen procaspase 1.

Vcp p97 also called cdc48 in yeast and plants cdc 48 in worms and ter94 in flies is a hexameric protein of the aaa atpases associated with diverse cellular activities family the members of which generally use the energy of atp hydrolysis to structurally remodel client molecules erzberger and berger 2006 vcp p97 has two atpase domains d1 and d2 which are organized as. Sanger a 1 hirst j 1 davies ak 1 robinson ms 2. Adaptor proteins aps are a family of currently five closely related protein complexes with key functions in vesicle trafficking. 1 cambridge institute for medical research university of cambridge cambridge cb2 0xy uk.

Adaptor protein ap complexes are heterotetramers that select cargo for inclusion into transport vesicles. Adaptor protein complexes and disease at a glance.