They bind to sorting signals in the cytoplasmic tails of cargo proteins recruit clathrin and other accessory proteins and then concentrate the cargo proteins into vesicular carriers which transport from the donor membrane to the target organelle membrane figure 1. Clathrin is a protein that plays a major role in the formation of coated vesicles clathrin was first isolated and named by barbara pearse in 1976. This is how clathrin gets its name from the latin clathratus meaning.
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