Adaptor Related Protein Complex

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 ap2 adaptors complex found in clathrin coated vesicles the ap 2 complex is a heterotetramer consisting of two large adaptins alpha or beta a medium adaptin mu and a small adaptin sigma.

Adaptor related protein complex. In humans ap 4 deficiency causes a severe neurological disorder of unknown aetiology. The steroid hormone nuclear ppars and the retinoid x receptors rxrs are important transcriptional factors that regulate gene expression cell differentiation and lipid metabolism. This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 ap 2 complex found in clathrin coated vesicles. The ap 2 complex is a heterotetramer consisting of two large adaptins alpha or beta a medium adaptin mu and a small adaptin sigma.

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the golgi complex where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. We propose that by analogy with ap 1 and ap 2 the complex should be called ap 3. Darnell and margaret s. The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles.

Ap50 is a 50 kd component of the ap2 coat assembly protein complex of clathrin coated vesicles. A novel adaptor related protein complex fiona simpson nicholas a. Robinson department of clinical biochemistry. Ap 2 complex subunit alpha 1 is a protein that in humans is encoded by the ap2a1 gene.

Thus we have correctly identified the two missing subunits of the adaptor related complex. 615781 adaptor related protein complex 1 sigma 3 subunit. The complex consists of 2 large 100 kd components which are called the alpha and beta subunits a 50 kd component ap50 and a small 17 kd protein summary by thurieau et al 1988. Adaptor protein 4 ap 4 is an ancient membrane trafficking complex whose function has largely remained elusive.

Like a conventional adaptor the complex consists of an α γ like subunit δ a β subunit a μ subunit and a σ subunit. A peroxisome proliferator actived receptor ppar response element re in the promoter region of the adaptor related protein complex 2 alpha 2 subunit ap2α2 of mouse heart has been identified.